Denver Advanced Neurological Treatment Center
|

 

Contact Advanced Neurological Evaluation and Treatment Center of Denver ADVANCED NEUROLOGICAL EVALUATION AND TREATMENT CENTER
1721 East 19th Avenue, Suite 510, Denver, CO 80218

Contact Dr.Feldman's office Maps/Directions

Rasmussen's Encephalitis


What is Rasmussen's Encephalitis?

Rasmussen's encephalitis is a rare, chronic inflammatory disease that usually affects only one hemisphere of the brain. It occurs in children under the age of 10 (and more rarely in adolescents and adults), and is characterized by frequent and severe seizures, loss of motor skills and speech, paralysis on one side of the body (hemiparesis), inflammation of the brain (encephalitis), and mental deterioration. Most individuals with Rasmussen's encephalitis will experience frequent seizures and brain damage over the course of the first 8 to 12 months, and then enter a phase of permanent, but stable, neurological deficits. Scientists currently think that Rasmussen's encephalitis is an autoimmune disease in which immune system cells enter the brain and cause inflammation and damage.

Is there any treatment?

Anti-epileptic drugs are usually not effective in controlling seizures. Recent studies have shown some success with treatments that suppress or modulate the immune system, in particular those that use corticosteroids, intravenous immunoglobulin, or tacrolimus. Surgery to control seizures may be performed in later stages of the disease when neurological deficits stabilize. Surgical procedures, such as functional hemispherectomy and hemispherotomy, may reduce the frequency of seizures and also improve behavior and cognitive abilities.

What is the prognosis?

The prognosis for individuals with Rasmussen's encephalitis varies. Despite the advances in medical treatment, none has yet been shown to halt the progress of the disease in the long term. The disorder may lead to severe neurological deficits or it may cause only milder impairments. For some children, surgery decreases seizures. However, most individuals with Rasmussen's encephalitis are left with some paralysis, cognitive deficits, and problems with speech.

What research is being done?

The National Institute of Neurological Disorders and Stroke (NINDS) conducts research related to Rasmussen's encephalitis in its laboratories at the National Institutes of Health (NIH), and also supports additional research through grants to major medical institutions across the country. Much of this research focuses on finding better ways to prevent, treat, and ultimately cure progressive neurological disorders, such as Rasmussen's encephalitis.

 

Return to disorders index

 

Dr.Alexander Feldman, Denver NeurologistMeet Dr. Alexander Feldman and other specialists in Advanced Neurological Evaluation and Treatment Center of Denver.