Denver Advanced Neurological Treatment Center
|

 

Contact Advanced Neurological Evaluation and Treatment Center of Denver ADVANCED NEUROLOGICAL EVALUATION AND TREATMENT CENTER
1721 East 19th Avenue, Suite 510, Denver, CO 80218

Contact Dr.Feldman's office Maps/Directions

Olivopontocerebellar Atrophy


What is Olivopontocerebellar Atrophy?

Olivopontocerebellar atrophy (OPCA) is a term that describes the degeneration of neurons in specific areas of the brain – the cerebellum, pons, and inferior olives. OPCA is present in several neurodegenerative syndromes, including inherited and non-inherited forms of ataxia (such as the hereditary spinocerebellar ataxia known as Machado-Joseph disease) and multiple system atrophy (MSA), with which it is primarily associated. http://www.ninds.nih.gov/disorders/msa/msa.htm

OPCA may also be found in the brains of individuals with prion disorders and inherited metabolic diseases. The characteristic areas of brain damage that indicate OPCA can be seen by imaging the brain using CT scans or MRI studies.

Is there any treatment?

There is no specific treatment for OPCA. Physicians may try different medications to treat the ataxia, tremor, and rigidity that are associated with the disorder. Other treatments are directed at specific symptoms. Stiffness, spasms, sleep disorders, depression, and tremor may be improved with medication. A physical therapist may be helpful in establishing a routine of exercise and stretching, and in obtaining devices or appliances to assist in walking and other daily activities.

What is the prognosis?

There is no cure for OPCA. The disorder is slowly progressive with death usually occurring approximately 20 years after onset.

What research is being done?

The NINDS supports and conducts a broad range of basic and clinical research on cerebellar degeneration, including work aimed at finding the cause(s) of OPCA and ways to treat, cure, and, ultimately, prevent the disease. There has been great progress recently since the genes for several of the hereditary forms of OPCA have been found.

 

Return to disorders index

 

Dr.Alexander Feldman, Denver NeurologistMeet Dr. Alexander Feldman and other specialists in Advanced Neurological Evaluation and Treatment Center of Denver.