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1721 East 19th Avenue, Suite 510, Denver, CO 80218

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Hereditary Spastic Paraplegia

Synonym:  Familial Spastic Paralysis



What is Hereditary Spastic Paraplegia?

Hereditary spastic paraplegia (HSP), also called familial spastic paraparesis (FSP), refers to a group of inherited disorders that are characterized by progressive weakness and spasticity (stiffness) of the legs. Early in the disease course, there may be mild gait difficulties and stiffness. These symptoms typically slowly progress so that eventually individuals with HSP may require assistance of a cane, walker, or wheelchair. Though the primary features of HSP are progressive lower extremity spasticity and weakness, more complicated forms may be accompanied by other symptoms. These symptoms include conditions that affect the optic nerve and retina of the eye, cataracts, ataxia (lack of muscle coordination), epilepsy, cognitive impairment, peripheral neuropathy, and deafness. The diagnosis of HSP is primarily by neurological examination and testing to rule out other disorders. Several genetic mutations have been identified which underlie some of the forms of HSP, and specialized genetic testing and diagnosis are available at some medical centers.

Is there any treatment?

There are no specific treatments to prevent, slow, or reverse HSP. Symptomatic treatments used for spasticity are sometimes helpful. Regular physical therapy is important for muscle strength and to preserve range of motion.

What is the prognosis?

The prognosis for individuals with HSP varies Some individuals are very disabled and others have only mild disability. The majority of individuals with uncomplicated HSP have a normal life expectancy.

What research is being done?

The NINDS supports research on genetic disorders such as HSP. Genes that are responsible for several forms of HSP have already been identified, and many more will likely be identified in the future. Understanding how these mutations cause HSP will lead to ways to prevent, treat, and cure HSP.





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